Though TMG and DMG differ in many ways, the two substances both work to help modify comportment in children with behavioral challenges in fact, in one study, they produced nearly the exact same amount of positive impact.* 3 However, the same study showed twice as many adverse effects with TMG. However, DMG's potential for impacting triglycerides may make it a better choice for those with cholesterol concerns.* 2 Supporting Children with Behavioral Problems* Related Content: HOW MUCH METHYLATION SUPPORT IS TOO MUCH? DMG Has Less Direct Impact on Homocysteineīoth TMG and DMG support cardiovascular health by reducing homocysteine levels, a risk factor for cardiovascular conditions.* Those who have delicate homocysteine levels or other hormone concerns may want to choose TMG as it donates its methyl groups directly to homocysteine. So, the quantity in trimethyl versus dimethyl is not the be all end all.

For example, if you are focused on the direct number of methyl groups donated, taking a ⅓ higher dose of DMG would put you at the same methyl donation count as TMG. However, dosage plays a key role, so it’s important to consider how the body uses the metabolite versus the number of methyl groups being produced. In other words, you might get both substances into your system, but DMG is transferred more effectively than TMG. Since DMG is neutral, it crosses the blood-brain barrier easier. TMG is also an osmolyte, a substance that has protective qualities and stabilizes proteins. The fact that they use completely different systems to donate to the methyl pool also means that TMG might work better for one person, where DMG works better for another.ĭifferent Charges Affect Absorption Efficiency Having two paths to get methyl groups into pool is like having a fail-safe system. Everything works together like a well-oiled machine, and in optimal circumstances, both TMG and DMG efficiently pump methyl groups into the methyl pool to produce SAM-e (S-Adenosyl methionine) from homocysteine. TMG transfers its methyl group directly to homocysteine, while DMG uses the folic acid (methylfolate) pathway. Both TMG and DMG are integral parts of the one-carbon cycle, and they both play critical roles in methylation pathways.* Proper methylation is essential for DNA replication and repair, energy production, immune response, stress support, and glutathione recycling.* Glutathione (the chief free radical fighter and detoxifier) is of particular importance, as without well-functioning methylation, the body doesn't produce glutathione.

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